VTCN1 / B7H4 antibody

Principal name

VTCN1 / B7H4 antibody

Alternative names for VTCN1 / B7H4 antibody

B7-H4, B7x, B7h.5, B7S1, UNQ659/PRO1291, V-set domain-containing T-cell activation inhibitor 1

SwissProt ID

Q501W4 (Rat), Q7TSP5 (Mouse), Q7Z7D3 (Human)

Gene ID

79679 (VTCN1), 242122 (Vtcn1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

Frozen Sections (C), Flow Cytometry (F), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of VTCN1 / B7H4 antibody

B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell responses. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of cell-mediated immunity in peripheral tissues.

General readings

Fauci,J.M., et al. (2012) Gynecol. Oncol. 127 (2), 420-425
Galazka,K., et al. (2012) Am. J. Reprod. Immunol. 68 (1), 85-93

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

VTCN1 / B7H4 (153-165) antibody

Staining of Human Spleen lysate (35µg protein in RIPA buffer) using VTCN1 Antibody Cat.-No AP31843PU-N at 0.2 µg/ml. Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

VTCN1 / B7H4 antibody

TA302632 (0.3µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

VTCN1 / B7H4 antibody

Anti-VTCN1 / B7-H4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. Mouse IgG1 H74 Aff - Purified Hu F, P
50 µg / €345.00
  OriGene Technologies, Inc.

VTCN1 / B7H4 antibody

Western blot analysis of VTCN1 in EL4 cell lysate with VTCN1 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

VTCN1 / B7H4 antibody

Staining of non-transfected (left) and mouse B7-H4 transfected (right) L5178Y cells with 0.25 ug Rat IgG2b kappa Isotype Control Purified (open histogram) or 0.25 ug Anti-Mouse B7-H4 Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE . Total viable cells were used for analysis. Rat 188 Purified Ms F
25 µg / €120.00
  OriGene Technologies, Inc.

VTCN1 / B7H4 antibody

Staining of non-transfected (left) and human B7-H4-transfected (right) HEK 293T cells with 0.125 ug of Mouse IgG1 kappa Isotype Control Purified (open histogram) or 0.125 ug of Anti-Human B7-H4 Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE .  Total cells were used for analysis. Mouse H74 Purified Hu F
25 µg / €150.00
  OriGene Technologies, Inc.

VTCN1 / B7H4 antibody

Predicted cell location: Cytoplasm. Positive control: Human gastric and cervical cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human gastric cancer tissue using VTCN1 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

VTCN1 / B7H4 antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian and thyroid cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using VTCN1 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

VTCN1 / B7H4 antibody

Flow Cytometry: AM05618FC-N FITC conjugated B7-H4 antibody staining of Human peripheral blood monocytes. Mouse IgG1 MIH43 FITC Hu F
0.1 mg / €410.00
  Acris Antibodies GmbH

VTCN1 / B7H4 antibody

AM05618PU-L B7H4 antibody staining of Paraffin Embedded Human Breast carcinoma. Mouse IgG1 MIH43 Purified Hu C, F, P
0.2 mg / €490.00
  Acris Antibodies GmbH

VTCN1 / B7H4 antibody

AM05618PU-L B7H4 antibody staining of Paraffin Embedded Human Breast carcinoma. Mouse IgG1 MIH43 Purified Hu C, F, P
0.1 mg / €290.00
  Acris Antibodies GmbH

VTCN1 / B7H4 antibody

Flow Cytometry: AM05618RP-N B7-H4 antibody staining of Human peripheral blood monocytes. Mouse IgG1 MIH43 PE Hu F
100 Tests / €480.00
  Acris Antibodies GmbH

VTCN1 / B7H4 (Center) antibody

Western blot analysis of VTCN1 Antibody (Center) (AP54528PU-N) in T47D cell line lysates (35 µg/lane). VTCN1 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

VTCN1 / B7H4 antibody

293 overexpressing VTCN1 and probed with VTCN1 polyclonal antibody ( Cat # PAB7331 ) ( mock transfection in first lane), tested by Origene. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

VTCN1 / B7H4 antibody

Western Blot: B7-H4 Antibody [NBP1-06096] - HEK293 over expressing B7-H4 (RC210360) and probed with NBP1-06096 (mock transfection in first lane), tested by Origene. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

VTCN1 / B7H4 antibody

Immunohistochemistry: B7H4 Antibody (EP1165) [NBP1-40582] - Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-B7-H4 Rabbit IgG EP1165 Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

VTCN1 / B7H4 antibody

VTCN1 / B7H4 Rat IgG2b 188 Aff - Purified Ms F
0.1 mg / €440.00
  Novus Biologicals Inc.

VTCN1 / B7H4 antibody

VTCN1 / B7H4 Rat IgG2b 188 Aff - Purified Ms F
25 µg / €320.00
  Novus Biologicals Inc.

VTCN1 / B7H4 antibody

VTCN1 / B7H4 Mouse IgG1 H74 Aff - Purified Hu F
0.1 mg / €440.00
  Novus Biologicals Inc.

VTCN1 / B7H4 antibody

VTCN1 / B7H4 Mouse IgG1 H74 Aff - Purified Hu F
25 µg / €340.00
  Novus Biologicals Inc.

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