VZV / HHV-3 antibody

Principal name

VZV / HHV-3 antibody

Alternative names for VZV / HHV-3 antibody

Varizella zoster, HHV3

Gene ID

1487709 (ORF68)

Available reactivities

Hu (Human), Mky (Monkey), Vi (Virus)

Available hosts

Mouse

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of VZV / HHV-3 antibody

Varicella Zoster Virus (VZV), a member of the human herpes virus family, causes two distinct clinical manifestations: childhood chickenpox(Varicella) and shingles (zoster). Varicella is the outcome of the primary infection with VZV, whereas, zoster is the result of VZV reactivation from latently infected sensory ganglia which occurs predominantly in aging and immunosuppressed individuals. VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology. The known envelope glycoproteins (gB, gC, gE, gH, gI, gK, gL) correspond with those in HSV, however there is no equivalent of HSV gD. VZV virons are spherical and 150-200 nm in diameter. Its lipid envelope encloses the nucleocapsid of 162 capsomeres arranged in a hexagonal form. Its DNA is a single linear, double strand molecule, 125,000 nt long. Glycoprotein E (gE), a 623 amino acid type I integral membrane protein, is expressed on plasma membranes and in the cytoplasm of VZV infected cells, where it is presumed to be present in the membranes of intracellular vesicles or organelles. VZV gE complexes with gI in the rough endoplasmic reticulum, and most gE exists in the form of gE to gI heterodimers in infected cells. VZV gE is also a predominant component of the virion envelope. The functions of gE, which is encoded by ORF68, are of particular interest because it has been demonstrated that ORF68 is essential for VZV replication. In contrast, the genes for gE proteins can be deleted from herpes simplex virus and pseudorabies virus, albeit with significant reductions in infectivity in cell culture and in animal models. Since the VZV genome does not encode a homologue of gD, VZV gE may have functions that are usually segregated between gD and gE, or the gE to gI complex, in other alphaherpesviruses.

General readings

1. Weller, T.H., (1979), Varicella and Herpes Zoster. In:Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections, (Lennette, E.H. and Schmidt, N.J., eds.),
American Public Health Associations, Inc. Washington D.C., pp 375-398.
2. Drew, W.L., et al., (1980), Rapid diagnosis of varicella-zoster virus infection by direct immuno-fluorescence, Am. J. Clin. Pathol., 73:699-701.
3. Davison et al, (1986), New common nomenclature for glycoprotein gene of varicella-zoster virus and their glycosylated products, J. Virol., 57:1195-1197.
4. Sato, H., et al., (2003), “Varicella-Zoster Virus ORF47 Protein Kinase, which is required for Replication in Human T cells, and ORF66 Protein Kinase which is expressed during Latency, are dispensable for establishment of Latency”, Journal of Virology, 77(20): 11180-11185

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

VZV / HHV-3 antibody

VZV / HHV-3 Mouse IgG1 371 Purified C, ICC/IF
0.1 mg / €340.00
  Acris Antibodies GmbH

VZV / HHV-3 antibody

VZV / HHV-3 Mouse IgM 5B7 FITC ICC/IF
0.1 mg / €430.00
  Acris Antibodies GmbH

VZV / HHV-3 Glycoprotein B antibody

VZV / HHV-3 Mouse IgG1 SG2-2E6 Azide Free Hu C, ICC/IF, IP, WB
0.5 mg / €420.00
  Acris Antibodies GmbH

VZV / HHV-3 Ellen strain, Glycoprotein H (GPIII) antibody

Indirect IFA test on Fixed Human Lung Fibroblast Cells using Varicella-Zoster Virus Monoclonal antibody (VZV) (gpIII) Clone SG3 Cat.-No BM3012 at 
1/20 dilution. Mouse IgG1 SG3 Azide Free ICC/IF, IP, WB
0.5 mg / €420.00
  Acris Antibodies GmbH

VZV / HHV-3 Ellen strain, Glycoprotein IV (GI) antibody

VZV / HHV-3 Mouse IgG2a SG4 Azide Free ICC/IF, IP
0.5 mg / €420.00
  Acris Antibodies GmbH

VZV / HHV-3 antibody

VZV / HHV-3 Mouse cocktail Mixed Purified C, E, ICC/IF, IP, P, WB
0.7 mg / €680.00
  Acris Antibodies GmbH

VZV / HHV-3 antibody

VZV / HHV-3 Mouse IgM 5B7 FITC Vi ICC/IF
50 µg / €510.00
  Novus Biologicals Inc.

VZV / HHV-3 antibody

VZV / HHV-3 Mouse IgG1 NCP-1 Purified Mky ICC/IF, IP
0.125 mg / €260.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

VZV / HHV-3 (Ellen Strain)

VZV / HHV-3 Purified Infected cells are harvested and virus extracted by alkaline treatment and sonnication. Clarified by centrifugation the preparation is further purified on a sucrose density gradient. The resulting antigen preparation consists of a high concentration of virus and viral components as well as some cellular material. Embryonic lung cells
1 mg / €1,710.00
  Acris Antibodies GmbH

VZV / HHV-3 (Ellen Strain)

VZV / HHV-3 Purified Infected cells are harvested and antigen extracted by alkaline treatment, sonication and detergent extraction. Glycoproteins are isolated by column chromatography using Lecithin.
1 mg / €2,160.00
  Acris Antibodies GmbH

VZV / HHV-3 Glycoprotein E

VZV / HHV-3 viral > 95 % pure by SDS-PAGE
0.1 mg / €380.00
  Acris Antibodies GmbH

VZV / HHV-3 Ellen Strain, Glycoprotein E

VZV / HHV-3 Purified GS-4B Sepharose affinity chromatography. E. coli
1 mg / €1,040.00
  Acris Antibodies GmbH

12 Item(s)

per page
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