WIBG / PYM antibody

Principal name

WIBG / PYM antibody

Alternative names for WIBG / PYM antibody

Partner of Y14 and mago, Protein wibg homolog

SwissProt ID

Q640E9 (Xenla), Q6PH11 (Danre), Q8CHP5 (Mouse), Q9BRP8 (Human)

Gene ID

84305 (WIBG)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Rt (Rat), Ye (Yeast), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of WIBG / PYM antibody

Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.

General readings

Bono F,. et al. (2004) EMBO Rep. 5(3):304-10.
Gehring NH,,et al. (2009) Cell. 137(3):536-48.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-WIBG mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800099)(1:500) Mouse IgG1 UMAB207 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-WIBG mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800100)(1:500) Mouse IgG1 UMAB208 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-WIBG mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800101)(1:400) Mouse IgG2a UMAB209 Purified Hu P
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-WIBG mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800099)(1:500) Mouse IgG1 UMAB207 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-WIBG mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800100)(1:500) Mouse IgG1 UMAB208 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-WIBG mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 110C for 10 min, UM800101)(1:400) Mouse IgG2a UMAB209 Purified Hu P
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806496) Mouse IgG1 OTI5E2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806506) Mouse IgG1 OTI9C7 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA806508)(1:150) Mouse IgG1 OTI1E10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806605) Mouse IgG1 OTI2C1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WIBG / PYM antibody

Host: Rabbit; Target Name: Wibg; Sample Tissue: Mouse Thymus lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

WIBG / PYM antibody

WB Suggested Anti-WIBG Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: 721_B cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye WB
50 µg / €325.00
  OriGene Technologies, Inc.

WIBG / PYM antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-WIBG mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806390) Mouse IgG2a OTI11C5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WIBG / PYM antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY WIBG (RC202988, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-WIBG. Mouse IgG1 OTI8D7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WIBG / PYM antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY WIBG (RC202988, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-WIBG. Mouse IgG1 OTI2C7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WIBG / PYM (N-term) antibody

WIBG antibody (N-term) (AP54565PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human cervical tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the WIBG antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

WIBG / PYM (C-term) antibody

Human 721_B; WB Suggested Anti-WIBG Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: 721_B cell lysate; WIBG antibody - C-terminal region (ARP60533_P050) in Human 721_B cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

WIBG / PYM antibody

WIBG / PYM Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

WIBG / PYM antibody

Immunohistochemistry-Paraffin: WIBG Antibody [NBP1-92596] - Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

WIBG / PYM (transcript variant 1)

WIBG / PYM Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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