WISP2 antibody

Principal name

WISP2 antibody

Alternative names for WISP2 antibody

WISP-2, CCN5, CT58, CTGFL, CTGF-L, UNQ228/PRO261, WNT1-inducible-signaling pathway protein 2, Connective tissue growth factor-like protein, Connective tissue growth factor-related protein 58

SwissProt ID

O76076 (Human), Q9Z0G4 (Mouse)

Gene ID

8839 (WISP2), 22403 (Wisp2)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of WISP2 antibody

This gene encodes a member of the WNT1 inducible sigling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated sigling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-termil cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 sigling pathway that is relevant to malignt transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.

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