WT1 / Wilms tumor protein antibody

Principal name

WT1 / Wilms tumor protein antibody

Alternative names for WT1 / Wilms tumor protein antibody

WT33

SwissProt ID

O62651 (Pig), P19544 (Human)

Gene ID

7490 (WT1)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Chk (Chicken), Ze (Zebrafish), African clawed frog, Bov (Bovine), Eq (Equine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Frozen Sections (C)

Selected product citations ‐ of AP15857PU-M

1. Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, et al. The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76. doi: 10.1093/hmg/ddq397. Epub 2010 Sep 14. PubMed PMID: 20843830. 
2. Vasilopoulou, E;Kolatsi-Joannou, M;Lindenmeyer, MT;White, KE;Robson, MG;Cohen, CD;Sebire, NJ;Riley, PR;Winyard, PJ;Long, DA;2016Loss of endogenous thymosin β4 accelerates glomerular disease. Kidney Int. PubMed PMID: 27575556

Background of WT1 / Wilms tumor protein antibody

WT1 is a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm\'s tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms.This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm\'s tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.

General readings

Ruteshouser,E.C., (2008) Genes Chromosomes Cancer 47 (6), 461-470

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

WT1 / Wilms tumor protein antibody

Formalin-Fixed, Paraffin-Embedded Human Wilms tumor stained with WT1 antibody Cat.-No. AM00403SU-L using peroxidase conjugate and DAB chromogen. Note the nuclear staining of tumor cells. Mouse IgG1 6F-H2 Supernatant Hu P
1 ml / €360.00
  Acris Antibodies GmbH

WT1 / Wilms tumor protein (349-439) antibody

Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1E9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

WT1 / Wilms tumor protein (Center) antibody

WT1 Antibody (Center E361) (AP54572PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of WT1 Antibody (Center E361) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

3 Item(s)

per page
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