WWOX / FOR antibody

Principal name

WWOX / FOR antibody

Alternative names for WWOX / FOR antibody

WOX1, WWOXv1, WWOXv8, WOX2, WWOXv2, WOX3, WWOXdelta6-8, WWOXv4, WWOXdelta5-8, WWOXv3, FOR II, FOR2, FOR I, FOR1, FOR III, FOR3, FOR IV, WW domain-containing oxidoreductase, Fragile site FRA16D oxidoreductase

SwissProt ID

Q91WL8 (Mouse), Q9NZC7 (Human), Q9NZC7-3

Gene ID

51741 (WWOX)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Dot blot (Dot)

Background of WWOX / FOR antibody

WW domain-containing oxidoreductase (Wwox) proteins belong to a family of proteins (Wwox 1–Wwox 8) that are involved in regulation of programmed cell death. Human Wwox gene encodes a putative tumor suppressor WW domain-containing oxidoreductase Wwox1 (also known as Wwox or FOR). Wwox expression has been shown in prostate, lung, breast and other cancers. In addition, numerous aberrant Wwox mRNA transcripts have been found in cancer cells. Wwox gene maps to the common fragile site FRA16D on chromosome 16q23.3-24.1, is altered in breast, esophageal, and ovarian cancer (2). Wwox transcripts with missing Wwox exons are noted in 7 primary tumors (7 of 27; 25.9%) and 5 of 8 cell lines. In addition, loss of heterozygosity at the Wwox locus was observed in 10 primary lung tumors (2).
Wwox1 is a pro-apoptotic protein. In response to stress or apoptotic stimuli, WOX1 became phosphorylated at Tyr33, which enabled its complex formation with activated p53 and JNK1. The p53/Wwox1 complex translocated to the mitochondria and further to the nuclei to mediate apoptosis. Wwox1 mutants, which were inactivated for nuclear translocation or Tyr33 phosphorylation, failed to induce apoptosis, indicating that activation of Wwox1 via Tyr33 phosphorylation, followed by nuclear translocation, is essential for inducing cell death. Wwox1 induced apoptosis synergistically with p53. In contrast, transiently activated JNK1 induced anti-apoptotic response, and this protective activity inhibited Wwox1-induced apoptosis. Taken together, Wwox1 is involved in stress and apoptotic responses, and is likely to regulate the activation of both p53 and JNK1. In murine fetuses, WOX1 was present prevalently in the brainstem, spinal cord and peripheral nerve bundles, but its expression decreased after birth. In parallel, the expression of WOX1, as determined by Western blotting, was significantly reduced in the brain stem and spinal cord of adult mice. Notably, high levels of WOX1 immunoreactivity was observed in the neural crest-derived structures such as cranial and spinal ganglia and cranial mesenchyme during the late fetal stage. In the adult brain, WOX1 is abundant in the epithelial cells of the choroids plexus and ependymal cells, while a low to moderate level of WOX1 is observed within white matter tracts, such as axonal profiles of the corpus callosum, striatum, optic tract, and cerebral peduncle (3). WOX2 is significantly downregulated in the neurons of AD hippocampi (4). A neuronal protectvie hormone, 17-estradiol, also increase the binding of WOX1 and GSK-3 with Tau.

General readings

1. R. L. Friedman, S. P. Manly, M. McMahon, I. M. Kerr, and G. R. Stark, Cell, 38: 745-755, 1984 .Yendamuri S, Kuroki T, Trapasso F, Henry AC,
Dumon KR, Huebner K, Williams NN, Kaiser LR, Croce CM. WW domain containing oxidoreductase gene expression is altered in non-small cell lung
cancer. Cancer Res. 2003 Feb 15;63(4):878-81.
2. Chang NS, Doherty J, Ensign A, Lewis J, Heath J, Schultz L, Chen ST, Oppermann U. Molecular mechanisms underlying WOX1 activation during
apoptotic and stress responses. Biochem Pharmacol. 2003 Oct 15;66(8):1347-54. Related Articles, Links
3. Chang NS, Doherty J, Ensign A. JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis. J Biol Chem. 2003 Mar 14;278(11):9195-202. Epub 2003 Jan 06.
4. Sze CI, Su M, Pugazhenthi S, Jambal P, Hsu LJ, Heath J, Schultz L, Chang NS. Downregulation of WOX1 induces Tau phosphorylation in vitro: A potential role in Alzheimer's disease. J Biol Chem. 2004 May 7 Epub 2004 May 04.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

WWOX1/4 Control Peptide

WWOX1/4
0.25 mg / €250.00
  Acris Antibodies GmbH

WWOX1/4 (C-term) antibody

WWOX1/4 Rabbit IgG Aff - Purified Hu, Ms C, Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

WWOX / FOR antibody

3 ug of anti-WWOX immunoprecipitated the 46 kDa WWOX protein fromt he cytosol of Molt4 T-cells, treated with nocodazole (10uM, 24 hr.) to synchronize mitosis. Rabbit Purified Hu, Ms C, F
0.1 ml / €325.00
  OriGene Technologies, Inc.

WWOX / FOR antibody

Western blot analysis of MCF-7 cell lysates with anti-WWOX antibody (1:1000). Rabbit Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

WWOX / FOR antibody

Western blot analysis of extracts from HepG2 cells, using WWOX antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

WWOX / FOR Control Peptide

WWOX / FOR
0.25 mg / €250.00
  Acris Antibodies GmbH

WWOX / FOR (N-term) antibody

Western Blot of WWOX1 antibody (AP10374PU-N at 1/500 dilution) Rabbit IgG Aff - Purified Hu, Ms, Rt Dot, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

WWOX / FOR control peptide

WWOX / FOR
0.1 mg / €420.00
  Acris Antibodies GmbH

WWOX / FOR (WWOX2) (C-term) antibody

WWOX / FOR Rabbit IgG Aff - Purified Hu, Ms Dot, E
0.1 mg / €420.00
  Acris Antibodies GmbH

WWOX / FOR control peptide

WWOX / FOR
0.1 mg / €250.00
  Acris Antibodies GmbH

WWOX / FOR (WWOX3) antibody

WWOX / FOR Rabbit IgG Aff - Purified Hu, Ms Dot, E
0.1 mg / €420.00
  Acris Antibodies GmbH

WWOX / FOR antibody

Western blot (WB) analysis of WWOX antibody (Cat.-No.: AP20494PU-N) in extracts from HepG2 cells. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

WWOX / FOR (C-term) antibody

WWOX Antibody (C-term) (AP54576PU-N) western blot analysis in mouse testis tissue lysates (35 µg/lane). This demonstrates the WWOX antibody detected the WWOX protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

WWOX / FOR antibody

Western Blot analysis of WWOX expression in transfected 293T cell line (H00051741-T01) by WWOX MaxPab polyclonal antibody.

Lane 1: WWOX transfected lysate(20.79 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

WWOX / FOR antibody

Western Blot analysis of WWOX expression in transfected 293T cell line (H00051741-T01) by WWOX MaxPab polyclonal antibody.

Lane 1: WWOX transfected lysate(20.79 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

WWOX / FOR antibody

Human skin tissue was formalin-fixed and parafin-embeded. The WWOX polyclonal antibody was diluted 1 : 1000. Rabbit Hu, Ms E, ICC/IF, P, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

WWOX / FOR antibody

Western blot analysis of extracts from HepG2 cells, using WWOX Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

WWOX / FOR antibody

Western blot analysis of extracts from HepG2 cells, using WWOX Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

WWOX / FOR (C-term) antibody

Human COLO205; WB Suggested Anti-WWOX Antibody. . Titration: 1.0 ug/ml. . Positive Control: COLO205 Whole Cell. There is BioGPS gene expression data showing that WWOX is expressed in COLO205.; WWOX antibody - C-terminal region (ARP61394_P050) in Human COLO205 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

WWOX / FOR antibody

Western blot analysis of WWOX expression in Raji (A); mouse brain (B) whole cell lysates. Rabbit Aff - Purified Bov, Hu, Ms, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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