WWTR1 / TAZ antibody

Principal name

WWTR1 / TAZ antibody

Alternative names for WWTR1 / TAZ antibody

WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif

SwissProt ID

Q9EPK5 (Mouse), Q9GZV5 (Human)

Gene ID

25937 (WWTR1)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of WWTR1 / TAZ antibody

Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

General readings

Huang,W., et al. (2012) J. Biol. Chem. 287 (31), 26245-26253
Pan,J., et al. (2012) Oncol. Rep. 28 (1), 179-185

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

WWTR1 / TAZ antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-WWTR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503538) Mouse IgG2a OTI1H9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WWTR1 / TAZ antibody

Anti-WWTR1 mouse monoclonal antibody (TA503396) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY WWTR1(RC204082). Mouse IgG1 OTI1B5 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

WWTR1 / TAZ antibody

Anti-WWTR1 mouse monoclonal antibody (TA503438) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY WWTR1(RC204082). Mouse IgG2a OTI1A12 Purified Can, Hu, Mky, Ms F, ICC/IF, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

WWTR1 / TAZ antibody

Detection of TAZ protein in HEK 293 cell lysate Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

WWTR1 / TAZ antibody

Predicted band size: 44 kDa . Positive control: Jurkat and Hela cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1,2: Jurkat and Hela cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

WWTR1 / TAZ antibody

WB Suggested Anti-WWTR1 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

WWTR1 / TAZ antibody

Western Blot: TAZ Antibody [TA336683] - Western blot analysis of TAZ in MDCK cells using TA336683 at 1:250 dilution. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

WWTR1 / TAZ (C-term) antibody

WWTR1 Antibody (C-term) (AP54578PU-N) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the WWTR1 antibody detected the WWTR1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

WWTR1 / TAZ antibody

Immunoperoxidase of monoclonal antibody to WWTR1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Mouse IgG2a 1F1 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

WWTR1 / TAZ antibody

Western blot analysis of WWTR1 in 293 cell lysate with WWTR1 polyclonal antibody ( Cat# PAB11979 ). Rabbit Hu, Ms, Rt IP, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

WWTR1 / TAZ antibody

Human HepG2; WB Suggested Anti-WWTR1 Antibody Titration: 0.2-1 ug/ml. Positive Control: HepG2 cell lysate; WWTR1 antibody - N-terminal region (ARP32540_P050) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

WWTR1 / TAZ antibody

WWTR1 / TAZ Rabbit Biotin Hu IP, WB
0.1 ml / €360.00
  Novus Biologicals Inc.

WWTR1 / TAZ antibody

WWTR1 / TAZ Rabbit DyLight488 Hu IP, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

WWTR1 / TAZ antibody

WWTR1 / TAZ Rabbit HRP Hu IP, WB
0.1 ml / €390.00
  Novus Biologicals Inc.

WWTR1 / TAZ antibody

Immunohistochemistry-Paraffin: TAZ Antibody [NBP1-85067] - Immunohistochemical staining of human nasopharynx shows strong nuclear and cytoplasmic positivity in respiratory epithelial cells. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

WWTR1 / TAZ

WWTR1 / TAZ Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

WWTR1 / TAZ (1-400, His-tag)

WWTR1 / TAZ Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

WWTR1 / TAZ (1-400, His-tag)

WWTR1 / TAZ Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

WWTR1 / TAZ

WWTR1 / TAZ Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

WWTR1 / TAZ

WWTR1 / TAZ Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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