XBP1 / TREB5 antibody

Principal name

XBP1 / TREB5 antibody

Alternative names for XBP1 / TREB5 antibody

XBP-1, XBP2, X-box-binding protein 1, Tax-responsive element-binding protein 5

SwissProt ID

O35426 (Mouse), P17861 (Human), Q3SZZ2 (Bovin)

Gene ID

7494 (XBP1), 22433 (Xbp1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Can (Canine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), ChIP assay (ChIP)

Background of XBP1 / TREB5 antibody

XBP1 is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.

General readings

Davies,M.P., (2008) Int. J. Cancer 123 (1), 85-88

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

XBP1 / TREB5 antibody

  Goat Polyclonal Antibody against XBP1 / TREB5  
TA302701 (1µg/ml) staining of nuclear HeLa lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 (C-term) antibody

  Rabbit Polyclonal XBP-1 Antibody  
Western blot analysis of XBP-1 in PC-3 cell lysate with XBP-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 (N-term) antibody

  Rabbit Polyclonal XBP-1 Antibody  
Western blot analysis of XBP-1 in HepG2 cell lysate with XBP-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 (2-160) antibody

  Mouse XBP-1 Monoclonal Antibody  
Western blot analysis of 100 ng of XBP-1 recombinant protein with XBP-1 antibody at 1 ug/mL. Mouse IgG 3H1G4 Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 (2-160) antibody

  Mouse XBP-1 Monoclonal Antibody  
Western blot analysis of 100 ng of XBP-1 recombinant protein with XBP-1 antibody at 1 ug/mL. Mouse IgG 9B7E5 Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 antibody

  Anti-XBP1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human breast and thyroid cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using XBP1 antibody at dilution 1/60, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 antibody

  Anti-XBP1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human breast and thyroid cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using XBP1 antibody at dilution 1/70, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 antibody

  Rabbit Polyclonal anti-Xbp-1 (COOH terminus) Antibody  
Panel A: Western blot analysis of extracts from HepG2 untreated cells (lane 1),  HepG2 cells treated with 300 nM of thapsigargin overnight (lane 2), mouse liver cells (lane 3) and mouse brain cells (lane 4) using anti-XBP-1s antibody (poly6195). Rabbit IgG Poly6195 Purified Hu, Ms, Rt ChIP, P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 antibody

  Mouse Monoclonal anti-XBP-1s Antibody  
Extracts of untreated HepG2 cells (lane 1) and extracts of HepG2 cells treated with 300 nM thapsigargin (TG) for 16 hours (lane 2) were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti-Xbp-1s antibody (clone 143F). Proteins were visualized using a goat anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection. Mouse IgG2a 143F Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 antibody

  Rabbit Polyclonal XBP1 Antibody  
Immunohistochemistry: XBP1 Antibody [TA336840] - Staining of XBP1 in mouse bladder using DAB with hematoxylin counterstain. Rabbit Purified Hu, Ms C, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 antibody

  Rabbit Polyclonal Anti-XBP1 Antibody  
Western blot analysis of XBP1 expression in HepG2 cell lysate Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XBP1 / TREB5 antibody

Western blot analysis using XBP1 mouse mAb against XBP1(AA: 1-160)-hIgGFc transfected HEK293 cell lysate. Mouse IgG1 1C4 Ascites Hu E, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

XBP1 / TREB5 antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

XBP1 / TREB5 (N-term) antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

XBP1 / TREB5 (C-term) antibody

XBP1 Antibody (C-term) (AP54580PU-N) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the XBP1 antibody detected the XBP1 protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

XBP1 - human gene knockout kit via CRISPR

XBP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

XBP1 - human gene knockout kit via CRISPR

XBP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

XBP1 - human gene knockout kit via CRISPR

XBP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

XBP1 - human gene knockout kit via CRISPR

XBP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Xbp1 - mouse gene knockout kit via CRISPR

Xbp1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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