XCT / SLC7A11 antibody

Principal name

XCT / SLC7A11 antibody

Alternative names for XCT / SLC7A11 antibody

Cystine/glutamate transporter, CCBR1, Amino acid transport system xc, Solute carrier family 7 member 11, Calcium channel blocker resistance protein CCBR1

SwissProt ID

Q9UPY5 (Human), Q9WTR6 (Mouse)

Gene ID

23657 (SLC7A11), 26570 (Slc7a11)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Can (Canine), Mky (Monkey), Gorilla, Eq (Equine), Hst (Hamster), Prim (Primate)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of XCT / SLC7A11 antibody

System xc- is a cystine-glutamate exchange transporter that is composed of a light-chain subunit (xCT, SLC7A11) as well as a heavy-chain subunit (CD98hc, SLC3A2), and the xCT expression levels correlate with system xc-activity. SLC7A11 gene encodes xCT which is a multipass membrane protein with 12 transmembrane domains having both termini located intracellularly. xCT is widely expressed in various tissues and exert multiple roles such as pheomelanin production, cellular proliferation/metastasis, Kaposi's sarcoma herpesvirus (KSHV) entry into the host cells, learning and memory. Because cystine absorbed by cells via system xc- is rapidly reduced to cysteine for incorporation into GSH, the cell surface xCT expression is considered an important determint of intracellular redox balance. Most cells require little cystine uptake to sustain cellular protein biosynthesis and GSH production, however this is different in cancer cells which generate high ROS levels via enhanced metabolism and require high GSH levels to survive oxidative stress. Accordingly, xCT is expressed at high levels in various malignt tumors including leukemias, lymphomas, Karposi's sarcoma, pancreatic cancer, and brain cancer.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

XCT / SLC7A11 antibody

  Rabbit Polyclonal Antibody against XCT  
Detection of XCT in total human and mouse stomach lysate, respectively. 1 minute ECL exposure. Rabbit IgG Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XCT / SLC7A11 antibody

  Goat Polyclonal Antibody against SLC7A11  
TA303158 (0.02µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XCT / SLC7A11 antibody

  XCT / SLC7A11 Rabbit Polyclonal (N-Terminus) Antibody  
Anti-SLC7A11 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Gorilla, Hu, Mky
50 µg / €400.00
  OriGene Technologies, Inc.

XCT / SLC7A11 (N-term) antibody

  XCT / SLC7A11 Rabbit Polyclonal (N-Terminus) Antibody  
XCT / SLC7A11 Rabbit Aff - Purified Can, Eq, Hst, Hu, Mky, Prim, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

XCT / SLC7A11 antibody

  Rabbit Polyclonal Anti-SLC7A11 Antibody  
WB Suggested Anti-SLC7A11 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

XCT / SLC7A11 antibody

  Rabbit Polyclonal xCT Antibody  
Western Blot: xCT Antibody [TA336629] - Detection of XCT in total human stomach lysate using NB 300-317. 15 minute ECL exposure. Rabbit Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XCT / SLC7A11 antibody

  Rabbit Polyclonal Anti-SLC7A11 Antibody  
XCT / SLC7A11 Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XCT / SLC7A11 (N-term) antibody

XCT staining in the absorptive epithelia of intestinal villi. Rabbit IgG Aff - Purified Hu, Ms P, WB
0.1 ml / €380.00
  Neuromics Antibodies

Lysates

Catalog No.    

SLC7A11 overexpression lysate

SLC7A11 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SLC7A11 (mGFP-tagged) - Human solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11), 200 uL, >10^7 TU/mL

Lenti ORF particles, SLC7A11 (mGFP-tagged) - Human solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (SLC7A11), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Slc7a11 (GFP-tagged) - Mouse solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11), 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc7a11 (GFP-tagged) - Mouse solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11), 200 uL, >10^7 TU/mL  
200 µl / €1,120.00
  OriGene Technologies, Inc.

Lenti ORF particles, Slc7a11 (Myc-DDK-tagged) - Mouse solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11), 200 uL, >10^7 TU/mL

Lenti ORF particles, Slc7a11 (Myc-DDK-tagged) - Mouse solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 (Slc7a11), 200 uL, >10^7 TU/mL  
200 µl / €1,000.00
  OriGene Technologies, Inc.

12 Item(s)

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