XPA / XPAC antibody

Principal name

XPA / XPAC antibody

Alternative names for XPA / XPAC antibody

DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein

SwissProt ID

P23025 (Human), P27089 (Chick), Q64267 (Mouse)

Gene ID

7507 (XPA), 22590 (Xpa)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E)

Background of XPA / XPAC antibody

Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer due to deficiencies in the DNA repair enzymes. The most frequent mutations are found in the XP genes of group A through G and group V, which encode nucleotide excision repair proteins. The XPA gene encodes a 31 kDa zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair. The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription, and the XPG gene product is an endonuclease that cuts on the 3' side of a DNA lesion during nucleotide excision repair. Molecular defects in the XP variant (XPV) group maintain normal excision repair, yet they result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.

General readings

Pan Y.R., et al. (2009) Cell Cycle 8:655-664James, et al. (2005) Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

XPA / XPAC antibody

  Rabbit polyclonal anti-XPA antibody  
Western blot analysis of extracts from COLO205 cells, using XPA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XPA / XPAC antibody

  Anti-XPA Rabbit Polyclonal Antibody  
Predicted band size: 31 kDa . Positive control: HEK-293 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XPA / XPAC antibody

  XPA Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines , using XPA antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

XPA / XPAC antibody

  Rabbit Polyclonal Anti-XPA Antibody  
Western blot analysis on COLO205 cell lysate using XPA Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XPA / XPAC antibody

  Mouse monoclonal Anti-XPA Clone 5A2  
XPA / XPAC Mouse IgG2 5A2 Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XPA / XPAC antibody

  Rabbit Polyclonal XPA Antibody  
ELISA: XPA Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

XPA / XPAC antibody

The lysate of SW480 (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human XPA antibody(1:500 ~ 1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG3 AT37C5 Purified Hu E, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

XPA / XPAC antibody

The lysate of SW480 (30ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human XPA antibody(1:500 ~ 1:2000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG3 AT37C5 Purified Hu E, WB
50 µl / €220.00
  Acris Antibodies GmbH

XPA / XPAC antibody

Western blot (WB) analysis of XPA antibody (Cat.-No.: AP06479PU-N) in extracts from COLO205 cells. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

XPA / XPAC (C-term) antibody

Western blot analysis of XPA Antibody (C-term) (AP18245PU-N) in NCI-H460 cell line lysates (35ug/lane). XPA (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

XPA / XPAC antibody

XPA / XPAC Rabbit Serum Hu WB
0.1 ml / €340.00
  Acris Antibodies GmbH

XPA / XPAC antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using XPA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €230.00
  Assay Biotech

XPA / XPAC antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using XPA Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

XPA - human gene knockout kit via CRISPR

XPA - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

XPA - human gene knockout kit via CRISPR

XPA - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

XPA - human gene knockout kit via CRISPR

XPA - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

XPA - human gene knockout kit via CRISPR

XPA - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Xpa - mouse gene knockout kit via CRISPR

Xpa - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Xpa - mouse gene knockout kit via CRISPR

Xpa - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Xpa - mouse gene knockout kit via CRISPR

Xpa - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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