XPC / XPCC antibody

Principal name

XPC / XPCC antibody

Alternative names for XPC / XPCC antibody

p125, DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein

SwissProt ID

P51612 (Mouse), Q01831 (Human)

Gene ID

7508 (XPC)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Frozen Sections (C)

Background of XPC / XPCC antibody

The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

XPC / XPCC antibody

Left: HeLa cells stained with XPC (3.26) monoclonal antibody (NB 100-477).  Right: DAPI Staining Photo is kindly provided by Dr. S. Liu at U of Arizona. Mouse IgG 3.26 Purified Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

XPC / XPCC antibody

ELISA: XPC Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

XPC / XPCC antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

XPC / XPCC antibody

XPC / XPCC Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

XPC / XPCC antibody

XPC / XPCC Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

XPC / XPCC antibody

Detection limit for recombinant GST tagged XPC is approximately 0.03ng/ml as a capture antibody. Mouse IgG2a 6D11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

XPC / XPCC antibody

ELISA: XPC Antibody [25510002] Rabbit Hu E
50 µg / €440.00
  Novus Biologicals Inc.

XPC / XPCC antibody

Western Blot and Immunoprecipitation: XPC Antibody [NB100-58801] - Detection of Human XPC on HeLa whole cell lysate using NB100-58801. XPC was also immunoprecipitated by rabbit anti-XPC antibody NB100-58800. Rabbit Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

XPC / XPCC

XPC / XPCC Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

XPC / XPCC

XPC / XPCC Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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