XPNPEP1 antibody

Principal name

XPNPEP1 antibody

Alternative names for XPNPEP1 antibody

XPNPEPL, XPNPEPL1, Xaa-Pro aminopeptidase 1, X-Pro aminopeptidase 1, X-prolyl aminopeptidase 1 soluble, Cytosolic aminopeptidase P, Soluble aminopeptidase P, Aminoacylproline aminopeptidase

SwissProt ID

O54975 (Rat), Q1JPJ2 (Bovin), Q6P1B1 (Mouse), Q9NQW7 (Human)

Gene ID

7511 (XPNPEP1), 170751 (Xpnpep1), 170750

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine)

Available hosts

Mouse, Goat

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Paraffin Sections (P)

Background of XPNPEP1 antibody

Aminopeptidase P (AP-P; X-Pro aminopeptidase) has the unique ability to leave the N-terminal amino acid residue from peptides having proline as the penultimate amino acid residue. Biologically active peptides comprise an important and diverse class of extracellular chemical messengers that mediate a wide range of intercellular interactions. Several bioactive peptides including hormones, neuropeptides, neurotransmitters escape non-specific protease degradation by having an Xaa-Pro motif at their amino termini. Due to its cyclic nature, proline confers resistance to such peptide bonds so that aminopeptidases with broad specificity cannot act upon such peptides. There are a limited number of peptidases that act on peptide bonds involving a proline residue, such as dipeptidyl peptidase II (DPPII) and dipeptidyl peptidase W (DPPIV), and prolidase (which cleaves the Xaa-Pro bond only in dipeptides), or endopeptidases such as prolyl endopeptidase (which cleaves on the carbonyl side of proline residues within a protein or peptide). However, none of these enzymes have been reported to hydrolyze Xaa-Pro bonds located at the N-terminus of peptides and proteins. Therefore, role of AP-P is crucial in this respect. AP-P activity is ubiquitous and has been found in a wide range of organisms including bacteria, yeast and vertebrates. Mammalian AP-Ps exist in membrane-bound and cytosolic forms, which represent two distinct gene products. The cytosolic (soluble) form of aminopeptidase P is found in human leukocytes and rat brain.

General readings

Cottrell G.S., et al. (2000) Biochemistry 39:15121-15128.Li X., et al. (2008) J. Biol. Chem. 283:22858-22866.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

XPNPEP1 antibody

  anti-XPNPEP1 mouse monoclonal antibody, clone OTI1E3 (formerly 1E3)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-XPNPEP1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501383, Dilution 1:50) Mouse IgG1 OTI1E3 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

XPNPEP1 (C-term) antibody

  Goat Anti-XPNPEP1 Antibody  
TA305684 (0.1 ug/ml) staining of Mouse (A) and Rat (B) Small Intestine lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XPNPEP1 antibody

  anti-XPNPEP1 mouse monoclonal antibody, clone OTI1E7 (formerly 1E7)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-XPNPEP1 mouse monoclonal antibody. (TA501384) Mouse IgG1 OTI1E7 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

XPNPEP1 antibody

Staining of Aminopeptidase P in the tubulointerstitial blood vessels and in particular the blood vessels of the glomerulus (paraffin-embedded tissue-sections fixed in formalin) with anti-Rat Aminopeptidase-P Cat.-No DM3611P Mouse IgG1 JG12C9C10 Purified Rt C, ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

XPNPEP1 - human gene knockout kit via CRISPR

XPNPEP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

XPNPEP1 - human gene knockout kit via CRISPR

XPNPEP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

XPNPEP1 - human gene knockout kit via CRISPR

XPNPEP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Xpnpep1 - mouse gene knockout kit via CRISPR

Xpnpep1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Xpnpep1 - mouse gene knockout kit via CRISPR

Xpnpep1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Xpnpep1 - mouse gene knockout kit via CRISPR

Xpnpep1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Xpnpep1 - mouse gene knockout kit via CRISPR

Xpnpep1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

XPNPEP1

  Recombinant protein of human X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (XPNPEP1)  
XPNPEP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

XPNPEP1 (transcript variant 2)

  Recombinant protein of human X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (XPNPEP1), transcript variant 2.  
XPNPEP1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €399.00
  OriGene Technologies, Inc.

XPNPEP1 (1-623, His-tag)

XPNPEP1 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

XPNPEP1 (1-623, His-tag)

XPNPEP1 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

XPNPEP1 overexpression lysate

XPNPEP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

XPNPEP1 overexpression lysate

XPNPEP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, XPNPEP1 (mGFP-tagged) - Human X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (XPNPEP1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, XPNPEP1 (mGFP-tagged) - Human X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (XPNPEP1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, XPNPEP1 (mGFP-tagged)-Human X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (XPNPEP1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, XPNPEP1 (mGFP-tagged)-Human X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (XPNPEP1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,300.00
  OriGene Technologies, Inc.

Lenti ORF particles, XPNPEP1 (Myc-DDK tagged) - Human X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (XPNPEP1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, XPNPEP1 (Myc-DDK tagged) - Human X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (XPNPEP1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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