XPO1 / Exportin-1 antibody

Principal name

XPO1 / Exportin-1 antibody

Alternative names for XPO1 / Exportin-1 antibody

Exp1, CRM1, Chromosome region maintenance 1 protein homolog

SwissProt ID

O14980 (Human), Q6P5F9 (Mouse), Q80U96 (Rat)

Gene ID

7514 (XPO1), 103573 (Xpo1), 85252

Available reactivities

Bov (Bovine), Chimp (Chimpanzee), Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat), African clawed frog, Bt (Bat), Chk (Chicken), Eq (Equine), Fi (Fish), Hst (Hamster), Mky (Monkey), Op (Opossum), Prim (Primate), Rb (Rabbit), Xen (Xenopus), Bear, Por (Porcine), Ye (Yeast), Ze (Zebrafish), GP (Guinea Pig)

Available hosts

Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of XPO1 / Exportin-1 antibody

CRM1 (chromosome region maintenance 1 protein homolog) mediates the nuclear export of cellular proteins (cargoes) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, CRM1 binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The direction of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. CRM1 also mediates the nuclear export of the Rev protein of HIV-1 and Rex protein of HTLV-1. It is involved in Rex dimerization, U3 snoRNA transport from Cajal bodies to nucleoli.
CRM1 is also involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. CRM1 is also involved in the regulation NFAT and AP-1.

General readings

Cheong,J.K., (2008) J. Biol. Chem. 283 (17), 11661-11676

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

XPO1 / Exportin-1 antibody

WB Suggested Anti-XPO1 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

XPO1 / Exportin-1 antibody

Human Pineal Tissue; Rabbit Anti-XPO1 Antibody . Catalog Number: ARP40465_P050 . Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue . Observed Staining: Cytoplasmic in pinealocytes . Primary Antibody Concentration: 1:100 . Other Working Concentrations: 1/600 . Secondary Antibody: Donkey anti-Rabbit-Cy3 . Secondary Antibody Concentration: 1:200 . Magnification: 20X . Exposure Time: 0.5 - 2.0 sec .; Rabbit Anti-XPO1 Antibody (ARP40465_P050) ) in Human Pineal Tissue using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

XPO1 / Exportin-1 antibody

WB Suggested Anti-XPO1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: 293T cell lysate; XPO1 is supported by BioGPS gene expression data to be expressed in HEK293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

XPO1 / Exportin-1 antibody

Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: NIH/3T3 cells, Primary antibody: (XPO1 Antibody) at dilution 1/275, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XPO1 / Exportin-1 (390-408) antibody

Spleen: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Fi, Hst, Hu, Mky, Ms, Op, Prim, Rb, Rt, Xen P, WB
50 µg / €470.00
  Acris Antibodies GmbH

XPO1 / Exportin-1 (C-term) antibody

Western blot analysis of XPO1 antibody (C-term) (AP17839PU-N) in mouse bladder tissue lysates (35ug/lane). XPO1 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

XPO1 / Exportin-1 antibody

IHC analysis of human spleen. Using XPO1 polyclonal antibody ( Cat # PAB0296 ) at 10 µg/ml. Rabbit Bov, Chimp, Hu C, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

XPO1 / Exportin-1 antibody

Human Heart; Rabbit Anti-XPO1 antibody. Catalog Number: ARP40466 . Paraffin Embedded Tissue: Human Heart cell Cellular Data: cardiac cell of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; XPO1 antibody - middle region (ARP40466_P050) in Human Heart using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

Xpo1 - mouse gene knockout kit via CRISPR

Xpo1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

XPO1 / Exportin-1

XPO1 / Exportin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

XPO1 / Exportin-1

XPO1 / Exportin-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, XPO1 (mGFP-tagged)-Human exportin 1 (CRM1 homolog, yeast) (XPO1), 200 uL, >10^7 TU/mL

Lenti ORF particles, XPO1 (mGFP-tagged)-Human exportin 1 (CRM1 homolog, yeast) (XPO1), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, XPO1 (Myc-DDK-tagged)-Human exportin 1 (CRM1 homolog, yeast) (XPO1), 200 uL, >10^7 TU/mL

Lenti ORF particles, XPO1 (Myc-DDK-tagged)-Human exportin 1 (CRM1 homolog, yeast) (XPO1), 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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