XRCC1 antibody

Principal name

XRCC1 antibody

Alternative names for XRCC1 antibody

DNA repair protein XRCC1, X-ray repair cross-complementing protein 1

SwissProt ID

O54935 (Crigr), P18887 (Human), Q60596 (Mouse), Q9ESZ0 (Rat)

Gene ID

7515 (XRCC1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of XRCC1 antibody

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a 70 kDa protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.

General readings

General / background references:Cappelli E et al. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. J Biol Chem 272:23970-5 (1997). PubMed PMID: 9295348
Labudova O et al. The transcription of the XRCC1 gene in the heart of radiation-resistant and radiation-sensitive mice after ionizing irradiation. Pediatr Res 41:435-9 (1997). PubMed PMID: 9078548

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

XRCC1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of lung tissue using anti-XRCC1 mouse monoclonal antibody. (UM500037, dilution 1:50; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB40 Purified Hu, Mky
0.1 ml / €468.00
  OriGene Technologies, Inc.

UltraMAB

XRCC1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of lung tissue using anti-XRCC1 mouse monoclonal antibody. (UM500037, dilution 1:50; heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Mouse IgG1 UMAB40 Purified Hu, Mky
30 µl / €140.00
  OriGene Technologies, Inc.

UltraMAB

XRCC1 antibody

Western blot analysis of extracts (10ug) from 3 different cell lines by using anti-XRCC1 monoclonal antibody.(1:200) Mouse IgG1 OTI2G8 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

XRCC1 antibody

Immunohistochemical staining of paraffin-embedded colon tissue within the normal limits using anti-XRCC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500880, Dilution 1:50) Mouse IgG1 OTI2F8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

XRCC1 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-XRCC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500886) Mouse IgG1 OTI2D8 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

XRCC1 antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-XRCC1 rabbit polyclonal antibody. (TA590221) Rabbit IgG Purified Hu, Mky E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XRCC1 antibody

Western blot analysis of extracts from Jurkat cells, using XRCC1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XRCC1 antibody

XRCC1 Antibody (Center) (Cat. #TA324813) western blot analysis in A375 cell line lysates (15ug/lane).This demonstrates the XRCC1 antibody detected the XRCC1 protein (arrow). Rabbit IgG Purified Hu F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

XRCC1 antibody

Host: Rabbit; Target Name: XRCC1; Sample Tissue: MCF7 Whole Cell lysates; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

XRCC1 antibody

Western blot detection of XRCC1 in Raji,K562,Hela,Jurkat and THP-1 cell lysates using XRCC1 mouse mAb (1:1000 diluted).Predicted band size:82KDa.Observed band size:82KDa. Mouse IgG1 3F6-G7-F7 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XRCC1 antibody

Western blot analysis on Jurkat,COS7 and HuvEc cell lysate using XRCC1 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XRCC1 antibody

Anti-XRCC1 mouse monoclonal antibody (TA500847) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY XRCC1(RC204952). Mouse IgG1 OTI3C3 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

XRCC1 antibody

Anti-XRCC1 mouse monoclonal antibody (TA500881) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY XRCC1(RC204952). Mouse IgG1 OTI2E8 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

XRCC1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY XRCC1 (RC204952, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-XRCC1. Mouse IgG1 OTI2H8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

XRCC1 antibody

Figure 1. Western blot of HT29 cell lysate using anti-XRCC1 antibody (AM05323PU-N). Mouse IgG2a 144 Purified Hu C, P, WB
0.1 mg / €570.00
  Acris Antibodies GmbH

XRCC1 antibody

Immunohistochemistry (IHC) analyzes of XRCC1 antibody (Cat.-No.: AP06480PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

XRCC1 antibody

XRCC1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

XRCC1 antibody

Immunoperoxidase of purified MaxPab antibody to XRCC1 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml] Mouse Purified Hu E(detection), ICC/IF, P, WB
50 µg / €370.00
  Abnova Taiwan Corp.

XRCC1 antibody

XRCC1 MaxPab rabbit polyclonal antibody. Western Blot analysis of XRCC1 expression in mouse kidney. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

XRCC1 antibody

Western blot analysis of XRCC1 expression in HT-29 cell lysate using XRCC1 monoclonal antibody, clone 144 ( Cat # MAB1792 ). Mouse IgG2a 144 Hu P, WB
0.1 mg / €640.00
  Abnova Taiwan Corp.

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