XRCC6 / Ku70 antibody

Principal name

XRCC6 / Ku70 antibody

Alternative names for XRCC6 / Ku70 antibody

G22P1, TLAA, CTCBF, CTC75, DNA repair protein XRCC6, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, Lupus Ku autoantigen protein p70, 70 kDa subunit of Ku antigen, Thyroid-lupus autoantigen, CTC box-binding factor 75 kDa subunit

SwissProt ID

O93257 (Chick), P12956 (Human), P23475 (Mouse)

Gene ID

2547 (XRCC6)

Available reactivities

Hu (Human), Mky (Monkey), Rb (Rabbit), Xen (Xenopus), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), African clawed frog, Hst (Hamster), Prim (Primate)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E), Frozen Sections (C), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of XRCC6 / Ku70 antibody

The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 (or p86), which is also known by the synonym Ku-80 (or p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Both subunits of the Ku protein have been cloned, and a number of functions have been proposed for Ku, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA-binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters. A Ku-related protein designated the enhancer 1 binding factor (E1BF), composed of two subunits, has been identified as a positive regulator of RNA polymerase I transcription initiation.

General readings

Ajmani AK et al. Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis. J Exp Med 181:2049-58 (1995). PubMed PMID: 7759997
Wang J et al. Murine monoclonal antibodies specific for conserved and non-conserved antigenic determinants of the human and murine Ku autoantigens. Mol Biol Rep 18:15-28 (1993). PubMed PMID: 7694076

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ku70/80 (XRCC6/5) antibody

Ku70/80 (XRCC6/5) Mouse IgG1 KU729 Purified Hu, Prim C, ICC/IF, IP, P
0.2 mg / €390.00
  Acris Antibodies GmbH

Ku70/80 (XRCC6/5) antibody

Ku70/80 (XRCC6/5) Mouse IgG1 KU729 Purified Hu, Prim C, ICC/IF, IP, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Ku70/80 (XRCC6/5) antibody

Ku70/80 (XRCC6/5) Mouse IgG1 KU729 Purified Hu, Prim C, ICC/IF, IP, P
20 µg / €160.00
  Acris Antibodies GmbH

XRCC6 / Ku70 antibody

Western blot analysis of extracts from HepG2 cells, using Ku70 antibody (#TA311887).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Western blot analysis of XRCC6 Antibody (C-term) (Cat. #TA324799) in A2058 cell line lysates (35ug/lane).XRCC6 (arrow) was detected using the purified Pab. Rabbit IgG Purified Hu F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 4C2-1A6 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

XRCC6 / Ku70 antibody

Immunoperoxidase of monoclonal antibody to XRCC6 on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3ug/ml] Mouse IgG1 4C2-1A6 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

XRCC6 / Ku70 antibody

Human Heart; . Rabbit Anti-XRCC6 Antibody. . Catalog Number:. ARP34117 . Paraffin Embedded Tissue: Human cardiac cell . Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

XRCC6 / Ku70 antibody

Immunohistochemistry-Paraffin: Ku70 Antibody (N3H10) [NB100-1915] - Human tonsil stained with Ku antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of epithelial cells and lymphocytes. Mouse IgG2b N3H10 Purified Hu, Mky, Rb, Xen ICC/IF, IP, P, WB
0.5 ml / €410.00
  Novus Biologicals Inc.

XRCC6 / Ku70 antibody

Immunohistochemistry: Ku70 Antibody (EPR4027) [NBP1-40806] - Immunohistochemical staining of paraffin-embedded human testis tissue using anti-Ku70 Rabbit IgG EPR4027 Hu F, ICC/IF, IP, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

XRCC6 / Ku70 (N-term) antibody

TA302668 (0.1µg/ml) staining of HeLa cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
20 µg / €200.00
  Acris Antibodies GmbH

XRCC6 / Ku70 (N-term) antibody

TA302668 (0.1µg/ml) staining of HeLa cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Western blot analysis of extracts from K562 cells, using XRCC6 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Predicted cell location: Nucleus. Positive control: Human colon and ovarian cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human colon and ovarian cancer tissue using XRCC6 antibody at dilution 1/10, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Predicted cell location: Nucleus. Positive control: Human colon and esophagus cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human colon and esophagus cancer tissue using XRCC6 antibody at dilution 1/10, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

XRCC6 Antibody (Center) (Cat. #TA324800) western blot analysis in 293,A549 cell line lysates (35ug/lane).This demonstrates the XRCC6 antibody detected the XRCC6 protein (arrow). Rabbit IgG Purified Hu F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Western blot detection of Ku70 in Hela,A549,COS7 and K562 cell lysates using Ku70 mouse mAb (1:1000 diluted).Predicted band size:70KDa.Observed band size:67KDa. Mouse IgG1 7B1-E12-G4 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Western blot detection of Ku70 in Hela,A549,MCF7,Jurkat and Raji cell lysates using Ku70 mouse mAb (1:1000 diluted).Predicted band size:70KDa.Observed band size:70KDa. Mouse IgG2b 6H10-E9-G7 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Western blot analysis on HeLa cell lysate using Ku70 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

XRCC6 / Ku70 antibody

Western blot analysis on HeLa and HepG2 cell lysate using Ku70 Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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