ZBP1 antibody

Principal name

ZBP1 antibody

Alternative names for ZBP1 antibody

C20orf183, DLM1, Z-DNA-binding protein 1

SwissProt ID

Q8VDA5 (Rat), Q9H171 (Human), Q9QY24 (Mouse)

Gene ID

81030 (ZBP1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of ZBP1 antibody

Z-DNA binding protein 1 (ZBP-1) belongs to a family of proteins that contain the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RAN. Vertebrate ZBPs are induced by immunostimulation and are involved in host defense mechanisms. ZBP-1 initiates an innate immune response by binding to foreign DNA in the cytosol. ZBP-1 mediates activation of the innate immune system by facilitating DNA-mediated induction of type-1 IFN and expression of other related genes. Human ZBP-1 is most prominently expressed in lymphatic tissues. Besides its function in immunoresponse, it is up-regulated in mouse tumor stromal cells and is speculated to play a role in host defense again tumors. 
Structure: 429 amino acids with predicted molecular weight of 46.3 kD.
Distribution: Cytosol.
Function: Participates in the detection of DNA from viral, bacterial, and host origin by the host's innate immune system. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production.

General readings

Rothenburg,S., et al., (2002) Nucleic Acids Res. 30 (4), 993-1000

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ZBP1 (C-term) antibody

Western blot analysis of ZBP1 in mouse small intestine tissue lysate with ZBP1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ZBP1 antibody

WB Suggested Anti-ZBP1 Antibody; Titration: 5.0 ug/ml; Positive Control: HepG2 Whole Cell Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ZBP1 antibody

WB Suggested Anti-TRPM3 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:312500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ZBP1 antibody

ELISA: Z DNA binding protein Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

ZBP1 antibody

Western Blot: Extracts of 293E cells nontransfected (Lane A) and transfected with hZBP-1 (Lane B) were resolved by eletrophoresis, trasferred to nitrocellulose, and probed with anti-ZBP-1 Antibody Cat.-No AM33076PU (Clone RONOB19). Proteins were visualized using a goat anti-rat IgG secondary conjugated to HRP and chemiluminescence detection. Rat IgG2a RonoB19 Purified Hu F, ICC/IF, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

ZBP1 antibody

Western Blot: Extracts of 293E cells nontransfected (Lane A) and transfected with hZBP-1 (Lane B) were resolved by eletrophoresis, trasferred to nitrocellulose, and probed with anti-ZBP-1 Antibody Cat.-No AM33076PU (Clone RONOB19). Proteins were visualized using a goat anti-rat IgG secondary conjugated to HRP and chemiluminescence detection. Rat IgG2a RonoB19 Purified Hu F, ICC/IF, IP, WB
25 µg / €260.00
  Acris Antibodies GmbH

ZBP1 antibody

ZBP1 Mouse IgG1 2C10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ZBP1 antibody

Western blot analysis of ZBP1 in mouse small intestine tissue lysate with ZBP1 polyclonal antibody ( Cat # PAB13018 ) at ( A ) 0.5, ( B ) 1 and ( C ) 2 µg/ml. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

ZBP1 antibody

Human HepG2; WB Suggested Anti-ZBP1 Antibody. . Titration: 5.0 ug/ml. . Positive Control: HepG2 Whole Cell; ZBP1 antibody - middle region (ARP36711_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Hu
0.1 mg / €310.00
  AVIVA Systems Biology

ZBP1 antibody

ELISA: Z DNA binding protein Antibody [26170002] Rabbit Hu E
50 µg / €550.00
  Novus Biologicals Inc.

ZBP1 antibody

Immunohistochemistry-Paraffin: Z DNA binding protein Antibody [NBP1-76854] - Human small intestine tissue with ZBP1 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

ZBP1 antibody

ZBP1 Rabbit Purified Hu, Ms WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Western Blot/IP/ChiP Kits

Catalog No. Host Iso. Clone Pres. React. Applications  

ZBP1 Western Blot Kit

ZBP1 Western Blot Kit Hu
25 Western Blots / kit / €640.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ZBP1

ZBP1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

ZBP1 (full length, N-term HIS tag, transcript variant 1)

ZBP1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

ZBP1

ZBP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ZBP1

ZBP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ZBP1

ZBP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ZBP1

ZBP1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ZBP1 overexpression lysate

ZBP1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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