ZC3HC1 antibody

Principal name

ZC3HC1 antibody

Alternative names for ZC3HC1 antibody

NIPA, HSPC216, Nuclear-interacting partner of anaplastic lymphoma kinase (ALK), Zinc finger C3HC-type protein 1

SwissProt ID

Q86WB0 (Human)

Gene ID

51530 (ZC3HC1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of ZC3HC1 antibody

Entry into mitosis is essentially driven by cyclin B1, which is located in the cytoplasm throughout interphase, but accumulates in the nucleus just before mitosis occurs. Nuclear interaction partner of ALK (NIPA) plays a critical role in cyclin B1 regulation. NIPA is normally phosphorylated during G2 and M phases, resulting in an accumulation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation. Therefore, the accumulation of cyclin B1 is due to the inability of phosphorylated NIPA to bind to the molecule SCF, thereby preventing the degradation of cyclin B1. An absence of NIPA causes cyclin B1 to accumulate abnormally, leading to premature mitotic entry, loss of checkpoint control and genomic instability, which are all associated with cancer. The phosphorylated form of NIPA may also be involved in apoptotic signaling pathways.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ZC3HC1 antibody

Western blot analysis of NIPA antibody (Cat.-No.: AP20366PU-N) in extracts from COS7 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ZC3HC1 antibody

Western Blot analysis of ZC3HC1 expression in transfected 293T cell line (H00051530-T01) by ZC3HC1 MaxPab polyclonal antibody.

Lane 1: ZC3HC1 transfected lysate(23.32 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

ZC3HC1 pSer354 antibody

Western blot analysis of extracts from COS7 cells treated with HU 2nM 24h, using NIPA (Phospho-Ser354) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

ZC3HC1 pSer354 antibody

Western blot analysis of extracts from COS7 cells treated with HU 2nM 24h, using NIPA (Phospho-Ser354) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

ZC3HC1 antibody

Immunofluorescence analysis of HeLa cells, using NIPA (Ab-354) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

ZC3HC1 antibody

Immunofluorescence analysis of HeLa cells, using NIPA (Ab-354) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

ZC3HC1 antibody

Western Blot: NIPA Antibody [NBP1-19525] - extracts from COS7 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

ZC3HC1 antibody

ZC3HC1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

ZC3HC1 antibody

ZC3HC1 Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €290.00
  Novus Biologicals Inc.

ZC3HC1 antibody

Immunohistochemistry-Paraffin: NIPA Antibody [NBP1-82564] Immunohistochemical staining of human hippocampus shows strong nuclear and nuclear membranous positivity in neuronal cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

ZC3HC1 antibody

Immunohistochemistry-Paraffin: NIPA Antibody [NBP1-82565] - Immunohistochemical staining of human gall bladder shows nuclear and nuclear membrane positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ZC3HC1

ZC3HC1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ZC3HC1

ZC3HC1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ZC3HC1

ZC3HC1 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

ZC3HC1

ZC3HC1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ZC3HC1

ZC3HC1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ZC3HC1 293T Cell Transient Overexpression Lysate(Denatured)

ZC3HC1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

17 Item(s)

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