ZCCHC11 antibody

Principal name

ZCCHC11 antibody

Alternative names for ZCCHC11 antibody

Terminal uridylyltransferase 4, Kiaa0191, Tut4, Zinc finger CCHC domain-containing protein 11

SwissProt ID

B2RX14, Q5TAX3

Gene ID

23318 (ZCCHC11), 23381 (SMG5), 230594

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of ZCCHC11 antibody

ZCCHC11 is the uridylyltransferase that acts as a suppressor of microR (miR) biogenesis by specifically mediating the termil uridylation of some miRs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miR precursor. Uridylated pre-let-7 miRs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintence of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency.ZCCHC11 does not bind R by itself, recruited to pre-let-7 miRs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3' uridylation of miR-26A, a miR that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mR degradation.

General readings

1. Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30. Erratum in: Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121.
PMID: 16643855

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ZCCHC11 antibody

TA309516 (0.05µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ZCCHC11 antibody

WB Suggested Anti-ZCCHC11 Antibody Titration: 0.2-1 ug/ml; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ZCCHC11 (C-term) antibody

AP15877PU-N  ZCCHC11 antibody staining of Paraffin Embedded Human Lymph Node at 4 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P
0.1 mg / €340.00
  Acris Antibodies GmbH

ZCCHC11 antibody

ZCCHC11 MaxPab polyclonal antibody. Western Blot analysis of ZCCHC11 expression in human spleen. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

ZCCHC11 antibody

ZCCHC11 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

ZCCHC11 antibody

ZCCHC11 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

ZCCHC11 (Center) antibody

Human ACHN; WB Suggested Anti-ZCCHC11 Antibody Titration: 0.2-1 ug/ml. Positive Control: ACHN cell lysate; ZCCHC11 antibody - middle region (ARP58745_P050) in Human ACHN cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

ZCCHC11 antibody

ZCCHC11 Rabbit IgG Aff - Purified Ms WB
50 µg / €680.00
  Funakoshi Co., Ltd.

ZCCHC11 antibody

Immunohistochemistry-Paraffin: ZCCHC11/TUT4 Antibody [NB100-783] - (4µg/ml) staining of paraffin embedded Human Lymph Node. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat IgG Aff - Purified Hu E, P
0.1 mg / €400.00
  Novus Biologicals Inc.

ZCCHC11 antibody

Western Blot: ZCCHC11 Antibody [NBP1-42654]- Whole cell lysate from HeLa (5, 15 and 50 mcg) and 293T (T; 50 mcg) cells.   Affinity purified rabbit anti-ZCCHC11 antibody used for WB at 0.04 mcg/ml. Rabbit Hu WB
0.1 ml / €440.00
  Novus Biologicals Inc.

ZCCHC11 antibody

Immunohistochemistry-Paraffin: ZCCHC11 Antibody [NBP1-83026] - Immunohistochemical staining of human smooth muscle shows distinct cytoplasmic positivity. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

ZCCHC11 antibody

Immunohistochemistry-Paraffin: ZCCHC11 Antibody [NBP1-83027] - Immunohistochemical staining of human smooth muscle shows distinct cytoplasmic positivity. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ZCCHC11

ZCCHC11 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ZCCHC11

ZCCHC11 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ZCCHC11 293T Cell Transient Overexpression Lysate(Denatured)

ZCCHC11 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

15 Item(s)

per page
  • LinkedIn