ZCCHC11 antibody

Principal name

ZCCHC11 antibody

Alternative names for ZCCHC11 antibody

Terminal uridylyltransferase 4, Kiaa0191, Tut4, Zinc finger CCHC domain-containing protein 11

SwissProt ID

B2RX14, Q5TAX3

Gene ID

23318 (ZCCHC11), 230594 (Zcchc11)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB)

Background of ZCCHC11 antibody

ZCCHC11 is the uridylyltransferase that acts as a suppressor of microR (miR) biogenesis by specifically mediating the termil uridylation of some miRs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miR precursor. Uridylated pre-let-7 miRs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintence of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency.ZCCHC11 does not bind R by itself, recruited to pre-let-7 miRs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3' uridylation of miR-26A, a miR that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mR degradation.

General readings

1. Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30. Erratum in: Biochem Biophys Res Commun. 2007 Feb 23;353(4):1121.
PMID: 16643855

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ZCCHC11 antibody

  Goat Polyclonal Antibody against Terminal Uridylyltransferase 4 (mouse)  
TA309516 (0.05µg/ml) staining of Rat Brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ZCCHC11 antibody

  Rabbit Polyclonal Anti-ZCCHC11 Antibody - middle region  
WB Suggested Anti-ZCCHC11 Antibody Titration: 0.2-1 ug/ml; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ZCCHC11 (C-term) antibody

AP15877PU-N  ZCCHC11 antibody staining of Paraffin Embedded Human Lymph Node at 4 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ZCCHC11 - human gene knockout kit via CRISPR

ZCCHC11 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ZCCHC11 - human gene knockout kit via CRISPR

ZCCHC11 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ZCCHC11 - human gene knockout kit via CRISPR

ZCCHC11 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ZCCHC11 - human gene knockout kit via CRISPR

ZCCHC11 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Zcchc11 - mouse gene knockout kit via CRISPR

Zcchc11 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Zcchc11 - mouse gene knockout kit via CRISPR

Zcchc11 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Zcchc11 - mouse gene knockout kit via CRISPR

Zcchc11 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Zcchc11 - mouse gene knockout kit via CRISPR

Zcchc11 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Zcchc11 (GFP-tagged) - Mouse zinc finger, CCHC domain containing 11 (Zcchc11), 200 uL, >10^7 TU/mL

Lenti ORF particles, Zcchc11 (GFP-tagged) - Mouse zinc finger, CCHC domain containing 11 (Zcchc11), 200 uL, >10^7 TU/mL  
200 µl / €2,620.00
  OriGene Technologies, Inc.

Lenti ORF particles, Zcchc11 (Myc-DDK-tagged) - Mouse zinc finger, CCHC domain containing 11 (Zcchc11), 200 uL, >10^7 TU/mL

Lenti ORF particles, Zcchc11 (Myc-DDK-tagged) - Mouse zinc finger, CCHC domain containing 11 (Zcchc11), 200 uL, >10^7 TU/mL  
200 µl / €2,370.00
  OriGene Technologies, Inc.

13 Item(s)

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