ZFYVE26 antibody

Principal name

ZFYVE26 antibody

Alternative names for ZFYVE26 antibody

KIAA0321, Zinc finger FYVE domain-containing protein 26

SwissProt ID

Q5DU37 (Mouse), Q68DK2 (Human)

Gene ID

23503 (ZFYVE26), 211978 (Zfyve26)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts


Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of ZFYVE26 antibody

Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.� Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ZFYVE26 (C-term) antibody

  Rabbit Polyclonal SPG15 Antibody  
Western blot analysis of SPG15 in rat heart tissue lysate with SPG15 antibody at (A) 0.5 and (B) 1 µg/ml. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €371.00
  OriGene Technologies, Inc.

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