ZNF423 antibody

Principal name

ZNF423 antibody

Alternative names for ZNF423 antibody

Zinc finger protein 423, OAZ, KIAA0760, Olf1/EBF-associated zinc finger protein, Smad- and Olf-interacting zinc finger protein

SwissProt ID

O08961 (Rat), Q2M1K9 (Human), Q80TS5 (Mouse)

Gene ID

23090 (ZNF423)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Xen (Xenopus), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ZNF423 antibody

OAZ is a 30-zinc finger, DNA-binding factor that associates with members of the Smad family of transcription factors in response to BMP2 activation. Bone morphogenic proteins (BMPs), are the largest group within the TGF Beta growth factors superfamily and are involved in embryonic development, specifically the formation of left-right asymmetry, neurogenesis, organogenesis and skeletal development. BMPs bind to surface receptors, which then phosphorylate serine residues of specific Smad proteins to induce Smad translocation to the nucleus and transcriptional activation of BMP targeted genes. OAZ specifically cooperates with the BMP-activated Smads, namely Smad1, 5 and 8, in binding to the CAGAC and TGGAGC boxes within the BRE, or BMP response element, and activating transcription. OAZ contains a BMP signaling module formed by two clusters of fingers that individually associate with either the Smads or the BMP response element. Distinct regions of OAZ, separate from the modules involved in BMP regulation, also enable OAZ to function as a transcriptional partner of Olf-1/EBF in olfactory epithelium and lymphocyte development, indicating that, as a multi–zinc finger protein, OAZ may have dual roles in signal transduction during development.

5 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ZNF423 antibody

ZNF423 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
  OriGene Technologies, Inc.

ZNF423 antibody

ZNF423 Mouse IgG1 N328B/37 Supernatant Hu, Ms C, ICC/IF, WB
  Antibodies Incorporated


ZNF423 antibody

ZNF423 Mouse Hu WB
  Abnova Taiwan Corp.

ZNF423 antibody

ZNF423 Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt, Ze WB
  AVIVA Systems Biology

ZNF423 antibody

ZNF423 Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt, Xen, Ze WB
  Novus Biologicals Inc.

5 Item(s)

per page
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