ZP2 / ZPA antibody

Principal name

ZP2 / ZPA antibody

Alternative names for ZP2 / ZPA antibody

Zona pellucida sperm-binding protein 2, Zona pellucida glycoprotein ZP2, Zona pellucida protein A

SwissProt ID

O54767 (Rat), P20239 (Mouse), P42099 (Pig), P48829 (Rabit), Q05996 (Human), Q9BH10 (Bovin)

Gene ID

7783 (ZP2), 22787 (Zp2), 81828

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of ZP2 / ZPA antibody

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. ZP2 is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.

General readings

Furlong,L.I., (2005) Fertil. Steril. 83 (6), 1780-1790

16 Item(s)

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CRISPR

Catalog No. Species Donor Vector  

ZP2 - human gene knockout kit via CRISPR

ZP2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ZP2 - human gene knockout kit via CRISPR

ZP2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ZP2 - human gene knockout kit via CRISPR

ZP2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ZP2 - human gene knockout kit via CRISPR

ZP2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Zp2 - mouse gene knockout kit via CRISPR

Zp2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Zp2 - mouse gene knockout kit via CRISPR

Zp2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Zp2 - mouse gene knockout kit via CRISPR

Zp2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Zp2 - mouse gene knockout kit via CRISPR

Zp2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ZP2 / ZPA

  Recombinant protein of human zona pellucida glycoprotein 2 (sperm receptor) (ZP2)  
ZP2 / ZPA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

ZP2 overexpression lysate

ZP2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ZP2 (mGFP-tagged) - Human zona pellucida glycoprotein 2 (sperm receptor) (ZP2), 200 uL, >10^7 TU/mL

Lenti ORF particles, ZP2 (mGFP-tagged) - Human zona pellucida glycoprotein 2 (sperm receptor) (ZP2), 200 uL, >10^7 TU/mL  
200 µl / €1,630.00
  OriGene Technologies, Inc.

Lenti ORF particles, ZP2 (Myc-DDK tagged) - Human zona pellucida glycoprotein 2 (sperm receptor) (ZP2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, ZP2 (Myc-DDK tagged) - Human zona pellucida glycoprotein 2 (sperm receptor) (ZP2) , 200 uL, >10^7 TU/mL  
200 µl / €1,470.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Zp2 (GFP-tagged) - Mouse zona pellucida glycoprotein 2 (Zp2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Zp2 (GFP-tagged) - Mouse zona pellucida glycoprotein 2 (Zp2), 200 uL, >10^7 TU/mL  
200 µl / €1,400.00
  OriGene Technologies, Inc.

Lenti ORF particles, Zp2 (Myc-DDK-tagged) - Mouse zona pellucida glycoprotein 2 (Zp2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Zp2 (Myc-DDK-tagged) - Mouse zona pellucida glycoprotein 2 (Zp2), 200 uL, >10^7 TU/mL  
200 µl / €1,260.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Zp2 (GFP-tagged ORF) - Rat zona pellucida glycoprotein 2 (sperm receptor) (Zp2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Zp2 (GFP-tagged ORF) - Rat zona pellucida glycoprotein 2 (sperm receptor) (Zp2), 200 uL, >10^7 TU/mL  
200 µl / €1,380.00
  OriGene Technologies, Inc.

Lenti ORF particles, Zp2 (Myc-DDK-tagged ORF) - Rat zona pellucida glycoprotein 2 (sperm receptor) (Zp2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Zp2 (Myc-DDK-tagged ORF) - Rat zona pellucida glycoprotein 2 (sperm receptor) (Zp2), 200 uL, >10^7 TU/mL  
200 µl / €1,235.00
  OriGene Technologies, Inc.

16 Item(s)

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