ZP2 / ZPA antibody

Principal name

ZP2 / ZPA antibody

Alternative names for ZP2 / ZPA antibody

Zona pellucida sperm-binding protein 2, Zona pellucida glycoprotein ZP2, Zona pellucida protein A

SwissProt ID

O54767 (Rat), P20239 (Mouse), P42099 (Pig), P48829 (Rabit), Q05996 (Human), Q9BH10 (Bovin)

Gene ID

7783 (ZP2), 4997783 (apaH)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of ZP2 / ZPA antibody

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. ZP2 is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.

General readings

Furlong,L.I., (2005) Fertil. Steril. 83 (6), 1780-1790

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ZP2 / ZPA antibody

Western Blot analysis of ZP2 expression in transfected 293T cell line (H00007783-T01) by ZP2 MaxPab polyclonal antibody.

Lane 1: ZP2 transfected lysate(80.96 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

ZP2 / ZPA antibody

ZP2 / ZPA Mouse IgG2a 2B9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ZP2 / ZPA antibody

Human HepG2; WB Suggested Anti-ZP2 Antibody Titration: 2.5ug/ml. Positive Control: HepG2 cell lysate; ZP2 antibody - C-terminal region (ARP45470_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Por, Rb WB
0.1 mg / €310.00
  AVIVA Systems Biology

ZP2 / ZPA antibody

Western Blot: ZP2 Antibody [NBP1-59436] - This Anti-ZP2 antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 2.5ug/ml. Rabbit Purified Hu WB
0.1 mg / €360.00
  Novus Biologicals Inc.

ZP2 / ZPA antibody

Immunohistochemistry-Paraffin: ZP2 Antibody [NBP1-86103] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ZP2 / ZPA

ZP2 / ZPA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ZP2 / ZPA

ZP2 / ZPA Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ZP2 / ZPA

ZP2 / ZPA Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

ZP2 / ZPA

ZP2 / ZPA Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ZP2 / ZPA

ZP2 / ZPA Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ZP2 293T Cell Transient Overexpression Lysate(Denatured)

ZP2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

ZP2 overexpression lysate

ZP2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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