ZP3A / ZP3B antibody

Principal name

ZP3A / ZP3B antibody

Alternative names for ZP3A / ZP3B antibody

ZP3, ZP-3, ZPC, Zona pellucida sperm-binding protein 3, Zona pellucida glycoprotein ZP3, Zona pellucida protein C, Sperm receptor

SwissProt ID

P10761 (Mouse), P21754 (Human), P42098 (Pig), P48830 (Bovin), P48833 (Rabit), P97708 (Rat)

Gene ID

7784 (ZP3)

Available reactivities

Bov (Bovine), Hu (Human), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of ZP3A / ZP3B antibody

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene

General readings

Chamberlin,M.E., et al., (1990) Proc. Natl. Acad. Sci. U.S.A. 87 (16), 6014-6018

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ZP3A / ZP3B (Isoform ZP3B) antibody

Human HepG2; WB Suggested Anti-ZP3 Antibody Titration: 0.6ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; ZP3 antibody - C-terminal region (ARP35855_T100) in Human HepG2 cells using Western Blot Rabbit IgG Purified Bov, Hu, Rb WB
0.1 mg / €310.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ZP3A / ZP3B

ZP3A / ZP3B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

ZP3A / ZP3B

ZP3A / ZP3B Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ZP3 293T Cell Transient Overexpression Lysate(Denatured)

ZP3 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

4 Item(s)

per page
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