Alternative names for Zyxin antibody
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)
Background of Zyxin antibody
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008].
Beckerle MC Zyxin: zinc fingers at sites of cell adhesion. Bioessays. 19:949-57 (1997). PubMed PMID: 9394617
Nix DA & Beckerle MC Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol. 138:1139-47 (1997). PubMed PMID: 9281590
Macalma T et al. Molecular characterization of human zyxin. J Biol Chem. 271:31470-8 (1996). PubMed PMID: 8940160
Crawford AW & Beckerle MC Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem 266:5847-53 (1991). PubMed PMID: 2005121
- Special Price (1)
|Goat||Aff - Purified||Can, Hu||E, WB||
0.1 mg / €340.00
|Acris Antibodies GmbH|
Acris recommends this product for Western blotting.
|Goat||IgG||Aff - Purified||Can, Hu||E, WB||
0.1 mg / €360.00