Zyxin antibody

Principal name

Zyxin antibody

Alternative names for Zyxin antibody

Zyxin-2, ZYX

SwissProt ID

Q04584 (Chick), Q15942 (Human), Q62523 (Mouse)

Gene ID

7791 (ZYX)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Zyxin antibody

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008].

General readings

Beckerle MC Zyxin: zinc fingers at sites of cell adhesion. Bioessays. 19:949-57 (1997). PubMed PMID: 9394617
Nix DA & Beckerle MC Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol. 138:1139-47 (1997). PubMed PMID: 9281590
Macalma T et al. Molecular characterization of human zyxin. J Biol Chem. 271:31470-8 (1996). PubMed PMID: 8940160
Crawford AW & Beckerle MC Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem 266:5847-53 (1991). PubMed PMID: 2005121

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