Zyxin antibody

Principal name

Zyxin antibody

Alternative names for Zyxin antibody

Zyxin-2, ZYX

Selected pictures

Zyxin antibody - H00007791-M01
H00007791-M01 - Western Blot analysis of ZYX expression in transfected 293T cell line by ZYX monoclonal antibody (M01), clone 2C10-4A7.Lane 1: ZYX transfected lysate(61.3 KDa).Lane 2: Non-transfected lysate.
Zyxin antibody - H00007791-M01
H00007791-M01 - Immunofluorescence of monoclonal antibody to ZYX on HeLa cell . [antibody concentration 10 ug/ml]

SwissProt ID

Q04584 (Chick), Q15942 (Human), Q62523 (Mouse)

Gene ID

7791 (ZYX)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Can (Canine), Chk (Chicken), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of Zyxin antibody

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008].

General readings

Beckerle MC Zyxin: zinc fingers at sites of cell adhesion. Bioessays. 19:949-57 (1997). PubMed PMID: 9394617
Nix DA & Beckerle MC Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol. 138:1139-47 (1997). PubMed PMID: 9281590
Macalma T et al. Molecular characterization of human zyxin. J Biol Chem. 271:31470-8 (1996). PubMed PMID: 8940160
Crawford AW & Beckerle MC Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem 266:5847-53 (1991). PubMed PMID: 2005121

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
NBP1-90349

Zyxin antibody

Immunohistochemistry-Paraffin: Zyxin Antibody [NBP1-90349] - Immunohistochemical staining of human adrenal gland shows moderate granular cytoplasmic positivity in cortical cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  
H00007791-P01-10

Zyxin

Zyxin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €370.00
  Abnova Taiwan Corp.
H00007791-P01-25

Zyxin

Zyxin Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    
H00007791-PW1

ZYX (Human) IP-WB Antibody Pair

ZYX (Human) IP-WB Antibody Pair  
1 set / €690.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    
H00007791-T01

ZYX 293T Cell Transient Overexpression Lysate(Denatured)

ZYX 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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