Zyxin antibody

Principal name

Zyxin antibody

Alternative names for Zyxin antibody

Zyxin-2, ZYX

SwissProt ID

Q04584 (Chick), Q15942 (Human), Q62523 (Mouse)

Gene ID

7791 (ZYX), 22793 (Zyx)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Zyxin antibody

TRIM50 is an E3 ubiquitin-protein ligase.Focal adhesions are actin-rich structures that eble cells to adhere to the extracellular matrix and at which protein complexes involved in sigl transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-termil proline-rich domain and three LIM domains in its C-termil half. The proline-rich domain may interact with SH3 domains of proteins involved in sigl transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the sigl transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Altertive splicing results in multiple transcript variants that encode the same isoform.

General readings

Li B, Zhuang L, Trueb B, Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. The Journal of biological chemistry 2004 May 279 (19): 20401-10.

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